STUDYING THE EFFECT OF ANATOMICAL DIFFERENCE ON PULMONARY PERFUSION

Ammad Amin, Firas

4. term

Biomedical Engineering and Informatics, Master

2011

104

At forstå, hvordan sunde lunger bevæger luft (ventilation) og fordeler blod (perfusion), kan hjælpe os med at forstå sygdomme i lungerne. En almindelig antagelse er, at tyngdekraften påvirker, hvordan blodet fordeles i lungerne, men tidligere arbejde tyder på, at denne effekt er lille. Denne undersøgelse bruger en eksisterende model for perfusion (Mogensen et al., 2010) til at teste hypotesen om, at anatomiske forskelle på tværs af lungerne har den største betydning for, hvordan perfusionen varierer ned gennem lungen. Vi indførte to anatomiske gradienter i modellen: længden af lungeområder og antallet af kapillærer, der omgiver alveolerne (små luftblærer). Ved at justere disse gradienter blev modellen kalibreret til eksperimentelle data, der beskriver perfusionsfordelingen i rygleje (Jones et al., 2001). Derefter undersøgte vi hypotesen med computersimuleringer (in silico) af perfusion i maveleje for at vurdere, hvordan anatomi påvirker variationen i fordelingen. Resultaterne stemmer overens med studier, der peger på, at mønsteret i lungernes perfusion primært skyldes anatomiske forskelle.

Understanding how healthy lungs move air (ventilation) and distribute blood (perfusion) can inform our knowledge of lung disease. While gravity is often considered, prior work suggests it has only a minor effect on perfusion. This study uses an existing perfusion model (Mogensen et al., 2010) to test the hypothesis that anatomical differences across the lung have the largest impact on how perfusion varies from top to bottom. We implemented two anatomical gradients in the model: the length of lung regions and the number of capillaries surrounding the alveoli (tiny air sacs). By adjusting these gradients, the model was calibrated to experimental data describing perfusion distribution in the supine (lying on the back) position (Jones et al., 2001). We then explored the hypothesis with in silico simulations of perfusion in the prone (lying face down) position to assess how anatomy affects distribution heterogeneity. The results align with studies suggesting that the pattern of pulmonary perfusion is mainly driven by anatomical differences.

[This abstract was generated with the help of AI]

Download
View record in AAU Student Projects

Ammad Amin, Firas:

• Modeling the Anatomical Difference in Human Lungs (2011)
• Modeling the Anatomical Differences in Human Lungs (2011)