Modeling the Anatomical Differences in Human Lungs

Ammad Amin, Firas

4. term

Biomedical Engineering and Informatics, Master

2011

102

At forstå, hvordan raske lunger bevæger luft (ventilation) og leverer blod (perfusion), kan hjælpe med at forklare, hvad der går galt ved lungesygdom. Mange modeller inkluderer tyngdekraft, men dens effekt på perfusionsfordeling vurderes som lille. Dette studie bruger perfusionsmodellen fra Mogensen et al. (2010) til at teste hypotesen om, at anatomiske forskelle på tværs af lungerne er den vigtigste drivkraft for, hvordan perfusion fordeles ned gennem lungen. Vi indfører to gradvise anatomiske ændringer (gradienter): én i længde og én i antallet af kapillærer omkring alveolerne (de små luftblærer). Ved at justere disse gradienter kalibrerer vi modellen, så den passer til perfusionsmålinger fra Jones et al. (2001) i rygliggende stilling. Derefter udfører vi in silico-simuleringer i maveliggende stilling for at vurdere, hvordan anatomi påvirker heterogeniteten i perfusionen. Resultaterne stemmer overens med studier, der peger på, at anatomiske forskelle, snarere end tyngdekraft, i høj grad former mønstret for lungeperfusion.

Understanding how healthy lungs move air (ventilation) and deliver blood (perfusion) can clarify what goes wrong in lung disease. Many models include gravity, but its effect on perfusion distribution appears small. This study uses the perfusion model by Mogensen et al. (2010) to test the hypothesis that anatomical differences across the lungs are the main drivers of how perfusion is distributed down the lung. We implement two gradual anatomical changes (gradients): one in length and one in the number of capillaries surrounding the alveoli (the tiny air sacs). By adjusting these gradients, we calibrate the model to match perfusion measurements from Jones et al. (2001) in the supine (lying on the back) position. We then run in silico simulations in the prone (lying on the stomach) position to assess how anatomy influences perfusion heterogeneity. The results are consistent with studies indicating that anatomical differences, rather than gravity, largely shape the pattern of pulmonary perfusion.

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Ammad Amin, Firas:

• Modeling the Anatomical Difference in Human Lungs (2011)
• STUDYING THE EFFECT OF ANATOMICAL DIFFERENCE ON PULMONARY PERFUSION (2011)