Repeated measurements: The effect of Ibuprofen on wrist functions after Colles fracture
Translated title
Repeated measurements
Author
Wolsted, Lotte
Term
4. term
Education
Publication year
2018
Submitted on
2018-05-31
Abstract
Dette speciale undersøger, om ibuprofen har en gavnlig effekt på genvinding af håndledsfunktion efter kirurgisk behandlet Colles-fraktur. Patienter, der alle fik samme operation, blev inddelt i medicinbaserede behandlingsgrupper (herunder ibuprofen og placebo) i ugen efter indgrebet. Bevægelsesudslag (bøjning og rotation) af den skadede hånd blev målt i grader ved tre tidspunkter i løbet af det første år; den raske hånd blev målt som reference. For at analysere de gentagne målinger og sammenligne grupperne blev der først anvendt ANOVA og multivariat ANOVA som indledende indikatorer, derefter lineære mixed models med random effects til at håndtere individuelle forskelle og korrelation mellem målinger, og endelig generaliserede estimeringsligninger (GEE) til populationsgennemsnit uden fordelingsantagelser. Alle tre tilgange gav enslydende resultater: der var ingen signifikant forskel mellem behandlingsgrupperne, og ibuprofen viste ingen påviselig gavnlig effekt på helingsforløbet målt ved håndleddets mobilitet.
This thesis examines whether ibuprofen improves recovery of wrist function after surgically treated Colles fracture. Patients who all underwent the same procedure were assigned to medication-based treatment groups (including ibuprofen and placebo) during the week after surgery. Range of motion of the injured wrist (flexion/extension and rotation) was recorded in degrees at three time points within the first postoperative year, with the uninjured hand measured as a reference. To analyze the repeated measurements and compare groups, the study first used ANOVA and multivariate ANOVA for an initial indication, then linear mixed-effects models with random effects to account for individual differences and within-subject correlation, and finally generalized estimating equations (GEE) to estimate population-averaged effects without distributional assumptions. Across methods, the conclusions were consistent: there was no significant difference between treatment groups, and ibuprofen showed no demonstrable beneficial effect on recovery as assessed by wrist mobility.
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