A master thesis from Aalborg University
Functional Connectivity Analysis on Resting State Electroencephalography Signals Following Chiropractic Spinal Manipulation in Chronic Stroke Patients
[Funktionel konnektivitetsanalyse på hviletilstands elektroensfalografi signaler efter kiropraktisk behandling i patienter med kronisk slagtilfælde]
Author(s)
Term
4. term
Publication year
2019
Submitted on
2019-06-06
Pages
77 pages
Abstract
Background Stroke is a global problem affecting billions of people. Many of these patients suffers from post stroke impairments, which can both be present as cognitive and motor deficits, which results in a decline in life quality. Early and effective rehabilitation are therefore important for these patients, as recovery and mechanisms, like neuroplasticity, linked to recovery are maximized at the early stages of stroke. Methods The present study investigated chiropractic spinal manipulation (SM) and its effects on resting state functional connectivity in chronic stroke patients. Functional connectivity analysis were computed through the metrics of Mutual Information (MI) and Phase Lag Index (PLI). Non-parametric cluster based permutation test were used to asses the statistical significance of the dataset within both SM session and a control session and between the two, in order to evaluate the effect of the interventions. Results Significantly increased functional connectivity of PLI were found within the Default Mode Network (DMN), between the posterior cingulate cortex and parahippocampal regions, for the SM session. No significant changes occurred for the control session or for the MI metric. Conclusion These findings suggests that SM alters functional connectivity in the brain of chronic stroke patients. The patients might have experienced a decreased pain perception, episodic memory and spatial representation and navigation. But it is uncertain, as these effects were not included in the study. Therefore further research regarding the effects of these results and SM, taking into account further information, are needed in order to validate if stroke patients can benefit from SM in a rehabilitation program.
Keywords
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