A computerized model of the Cori cycle in patients with critical illness
Author
Kassebaum, Eric
Term
4. term
Publication year
2015
Submitted on
2015-06-03
Pages
152
Abstract
Critically ill patients often lose lean body mass due to increased metabolism, a process that can be life-threatening independent of the underlying cause. Providing external nutrition in the right amount, timing, and composition may mitigate progressive catabolism. To support this understanding, the project models the Cori cycle, which governs the exchange of glucose, lactate, and alanine between the liver, muscle, and other organs. The approach uses ordinary differential equations with Michaelis–Menten kinetics to represent cellular carbohydrate metabolism and extends this to a compartment model that captures accumulation and transport of metabolites between producing and consuming organs. The combined model is implemented as a LabVIEW-based computer program to simulate the Cori cycle over time in the context of critical illness. The excerpt does not report specific results or validation, but the work provides a basis for exploring metabolic responses and informing future studies of nutritional strategies for critically ill patients.
Kritisk syge patienter mister ofte fedtfri kropsmasse på grund af øget stofskifte, hvilket kan være livstruende uafhængigt af den underliggende årsag. Rigtig mængde, timing og sammensætning af ekstern ernæring kan muligvis dæmpe katabolismen over tid. For at støtte denne forståelse modellerer projektet Cori-cyklussen, som beskriver udvekslingen af glukose, laktat og alanin mellem lever, muskler og andre organer. Modellen er opbygget ved hjælp af differentialligninger baseret på Michaelis-Menten-kinetik for den cellulære kulhydratmetabolisme og udvidet til en kompartmentmodel, der beskriver ophobning og transport af metabolitter mellem producerende og forbrugende organer. Den kombinerede model er implementeret som et computerprogram i LabVIEW til simulering af Cori-cyklussen over tid i en kontekst med kritisk sygdom. Uddraget rapporterer ikke specifikke resultater eller validering, men arbejdet tilvejebringer et grundlag for at udforske metaboliske reaktioner og for at understøtte fremtidige studier af ernæringsstrategier hos kritisk syge.
[This apstract has been generated with the help of AI directly from the project full text]