Understanding the Impact of Diverse Antibiotics on Gut Bacteria Survival
Author
Term
4. term
Education
Publication year
2025
Submitted on
2025-05-31
Pages
78
Abstract
The human gut microbiota is composed of different commensal bacteria, fungi and viruses, essential for the host’s health: commonly prescribed antibiotics alter its composition, leading to dysbiosis. Previous studies have shown that bacteriostatic antibiotics, thought to be better for the health of gut bacteria, have bactericidal activity towards some strains. This study aims to investigate in more detail the diverse static-cidal effect of an array of different antibiotics against commensal bacteria commonly found in the gut microbiota. Through a high-throughput measurement, Minimum Inhibitory concentration (MIC) values are measured for bacteria of interest, not available on public databases, and needed to study the effect of various antibiotics on specific strains through a survival assay. This study concludes that the majority of previously defined bacteriostatic antibiotics actually show bactericidal effects.
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