Pharmacogenetic Aspects of Clozapine Treatment
Translated title
Farmakogenetiske Aspekter af Clozapin Behandling
Author
Andersen, Michelle Vandborg
Term
4. term
Publication year
2014
Pages
41
Abstract
At finde den rette behandling for skizofreni indebærer ofte forsøg og fejl. Når mindst to forskellige antipsykotiske lægemidler ikke virker, kaldes det behandlingsresistent skizofreni (omkring 30% af patienterne). Clozapin hjælper omtrent halvdelen af disse patienter, men er ikke førstevalg, fordi det kan give sjældne, men potentielt livstruende bivirkninger og derfor kræver tæt monitorering. Hvis man kunne forudsige, hvem der vil have gavn af clozapin, kunne effektiv behandling startes tidligere, og resultaterne forbedres. Denne afhandling undersøger, om farmakogenetik (hvordan genetiske forskelle påvirker lægemiddelrespons) kan hjælpe med at forudsige clozapinrespons. Efter en gennemgang af dopaminreceptorgener fokuserede vi på dopamin D2-receptorgenet og testede, om genetiske varianter heri var knyttet til respons på clozapin. I vores materiale fandt vi ingen sammenhæng mellem variation i D2-receptorgenet og respons på clozapin.
Finding the right treatment for schizophrenia still often involves trial and error. When at least two different antipsychotic medicines do not work, the condition is called treatment-resistant schizophrenia (about 30% of patients). Clozapine helps roughly half of these patients, but it is not used as a first choice because it can cause rare but potentially life-threatening side effects, so close monitoring is required. If we could predict who will benefit from clozapine, effective care could start sooner and outcomes could improve. This thesis examines whether pharmacogenetics (how genetic differences influence the way medicines work) can help predict clozapine response. After reviewing dopamine receptor genes, we focused on the dopamine D2 receptor gene and tested whether its genetic variants were linked to response to clozapine. In our sample, we found no association between D2 receptor gene variation and clozapine response.
[This abstract was generated with the help of AI]
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