Perceived stress levels and the risk of developing type 2 diabetes - a register based cohort study
Translated title
Subjektive stress niveau og risikoen for at udvikle type 2 diabetes - et register baseret cohort studie
Authors
Pedersen, Mathias Rothmann ; Vilhelmsen, Thomas Alexander Bjørnkær
Term
5. Term (Master thesis)
Education
Publication year
2018
Abstract
Dette registerbaserede, retrospektive kohortestudie undersøgte, om selvoplevet stress er forbundet med risikoen for at udvikle type 2-diabetes (T2D). I alt indgik 29.873 personer (50,7% mænd) i alderen 16–95 år fra Region Nordjylland, som besvarede Den Nationale Sundhedsprofil i 2010 eller 2013, herunder den validerede 10-item Cohen’s Perceived Stress Scale (PSS-10) til måling af oplevet stress. Nye T2D-tilfælde blev identificeret ved kobling til tre nationale registre (receptkøb, hospitalsudskrivningsdiagnoser og laboratoriemålinger) via unikke personnumre. Risikoestimater blev beregnet med Cox-regression på tværs af stressniveauer (lav, moderat, høj). Over en opfølgningsperiode på 3,7 år udviklede 503 deltagere T2D; den kumulative incidens steg fra 1,5% i lav-stressgruppen til 4,4% i høj-stressgruppen. Efter justering for deltagernes baseline-karakteristika var hazard ratio 1,36 (95% KI 1,13–1,64) for moderat stress og 2,08 (95% KI 1,21–3,57) for høj stress sammenlignet med lav stress. Fundene tyder på en positiv sammenhæng i tidsmæssig rækkefølge mellem højere grad af oplevet stress og øget risiko for T2D, målt med en valideret psykometrisk skala.
This register-based retrospective cohort study examined whether perceived stress is associated with the risk of developing type 2 diabetes (T2D). The cohort included 29,873 individuals (50.7% male) aged 16–95 years from the North Denmark Region who completed the Danish Health Profile in 2010 or 2013, including the validated 10-item Cohen’s Perceived Stress Scale (PSS-10). Incident T2D was ascertained by linkage to three national registers (prescriptions, hospital discharge diagnoses, and laboratory tests) using unique personal identifiers. Cox regression estimated risk across stress categories (low, moderate, high). Over 3.7 years of follow-up, 503 participants developed T2D; cumulative incidence increased from 1.5% in the low-stress group to 4.4% in the high-stress group. After adjustment for baseline characteristics, hazard ratios were 1.36 (95% CI 1.13–1.64) for moderate stress and 2.08 (95% CI 1.21–3.57) for high stress versus low stress. These findings indicate a positive, temporally ordered association between higher perceived stress and increased T2D risk, measured using a validated psychometric scale.
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