Health related quality of life and compliance in patients with rheumatoid arthritis treated with biologic subcutaneous drugs: a cross-sectional study
Translated title
Undersøgelse af livskvalitet og compliance hos reumatoid artirt patienter i en subkutan biologisk behandling: et cross-sectional studie
Author
Kristensen, Maria
Term
4. term
Publication year
2012
Submitted on
2012-05-31
Pages
25
Abstract
This cross-sectional study examined treatment adherence and health-related quality of life in Danish patients with rheumatoid arthritis (RA) receiving subcutaneous biologic drugs. Patients were recruited from eight rheumatology outpatient clinics, and 128 adults with RA (70.1% women; mean age 56 years) completed a questionnaire comprising the Compliance Questionnaire Rheumatology (CQR) and EuroQol EQ-5D. Adalimumab and etanercept were the most commonly used agents. The mean EQ-5D score was 0.729, and the mean CQR score was 20.8. A weak but statistically significant association was observed between dosing intervals and CQR, whereas no association was found with EQ-5D. In multivariable linear models, higher age was associated with a lower CQR (poorer adherence), female sex with lower EQ-5D, and higher educational level with higher EQ-5D. Overall, quality of life was comparable to other RA studies but lower than in the Danish general population, and CQR scores were lower than reported for methotrexate-treated RA patients, suggesting adherence challenges in this sample. Other unmeasured factors may also have influenced outcomes.
Dette tværsnitsstudie undersøgte efterlevelse (compliance) og helbredsrelateret livskvalitet hos danske patienter med reumatoid artrit (RA) i behandling med subkutane biologiske lægemidler. Patienterne blev rekrutteret fra otte reumatologiske ambulatorier, og 128 voksne med RA (70,1 % kvinder; gennemsnitsalder 56 år) udfyldte et spørgeskema bestående af Compliance Questionnaire Rheumatology (CQR) og EuroQol EQ-5D. De hyppigst anvendte præparater var adalimumab og etanercept. Den gennemsnitlige EQ-5D-score var 0,729, og den gennemsnitlige CQR-score var 20,8. Der blev fundet en svag, statistisk signifikant sammenhæng mellem administrationsintervaller og CQR, men ikke mellem administrationsintervaller og EQ-5D. I multivariable lineære modeller var højere alder forbundet med lavere CQR (ringe efterlevelse), mens kvindekøn var forbundet med lavere EQ-5D, og højere uddannelsesniveau med højere EQ-5D. Samlet set lå livskvaliteten på linje med andre RA-studier, men lavere end i den danske baggrundsbefolkning, og CQR-scoren var lavere end rapporteret hos RA-patienter i methotrexatbehandling, hvilket peger på efterlevelsesudfordringer i stikprøven. Andre, ikke målte faktorer kan også have haft betydning.
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Keywords
livskvalitet ; compliance ; CQR ; EQ-5D ; Reumatoid artrit