Emulsion Electrospinning Antibacterial Fibres with a 3D Printed Microfluidic Droplet Generator
Translated title
Emulsions elektrospinning af antibakterielle fibre ved hjælp af 3D printede mikrofluide dråbe generatorer
Author
Daugaard, Magnus Undall-Behrend
Term
4. term
Education
Publication year
2021
Submitted on
2021-06-03
Pages
47
Abstract
This thesis examines whether a 3D‑printed microfluidic droplet generator can be directly coupled to emulsion electrospinning to produce compartmentalized polymer fibers aimed at antibacterial applications. A 20% polyvinylpyrrolidone (PVP) solution served as the continuous phase and grapeseed oil with 100 mM tert‑butylbenzoquinone (TBBQ) as the dispersed phase. Droplets were generated at two flow‑rate pairs (continuous/dispersed: 80/16.5 and 50/12.5 μL/min), yielding average droplet diameters of 0.469 μm (SD 0.213) and 0.742 μm (SD 0.0159), while COMSOL Multiphysics (2D/3D) simulations predicted larger droplets (≈1.43–1.55 μm). The emulsion was electrospun directly from the device, producing fibers 0.897–2.486 μm in diameter with compartment features of 2.855–6.564 μm. Release profiles from two fiber samples showed distinct early‑time patterns but in both cases approached an equilibrium‑determined release. Overall, the results demonstrate the feasibility of on‑chip droplet generation for emulsion electrospinning and provide quantitative control ranges for droplet and fiber dimensions; antibacterial performance is not assessed in this excerpt.
Dette speciale undersøger, om en 3D‑printet mikrofluidisk dråbegenerator kan kobles direkte til emulsionselektrospinding for at fremstille kompartementerede polymerfibre med sigte på antibakterielle anvendelser. En 20 % polyvinylpyrrolidon (PVP)-opløsning blev brugt som kontinuerlig fase, mens grapekerneolie med 100 mM tert‑butylbenzoquinon (TBBQ) udgjorde den dispergerede fase. Dråber blev dannet ved to sæt flowhastigheder (kontinuer/dispergeret: 80/16.5 og 50/12.5 μL/min) og gav gennemsnitlige dråbediametre på henholdsvis 0.469 μm (SD 0.213) og 0.742 μm (SD 0.0159); COMSOL Multiphysics (2D/3D) simuleringer forudsagde større dråber (ca. 1.43–1.55 μm). Emulsionen blev elektrospundet direkte fra enheden og gav fibre med diametre på 0.897–2.486 μm og kompartementstrukturer på 2.855–6.564 μm. Frigivelsesprofiler for to fibersamples viste forskellige tidlige mønstre, men i begge tilfælde en ligevægtsbestemt frigivelse. Resultaterne demonstrerer gennemførligheden af on‑chip dråbedannelse til emulsionselektrospinding og giver kvantitative kontrolintervaller for dråbe- og fiberstørrelser; antibakteriel effekt er ikke vurderet i dette uddrag.
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