Bone Health Index in children with mild to moderate cerebral palsy - A pilot study
Translated title
Knoglesundhedsindex hos børn med mild til moderat cerebral parese - et pilotstudie.
Author
Hrustanovic, Iris
Term
4. term
Publication year
2019
Submitted on
2019-05-31
Abstract
Baggrund: Børn med cerebral parese (CP) har ofte vækst- og knogleudfordringer. Dette pilotstudie undersøgte forholdet mellem knoglealder og kronologisk alder samt faktorer, der kan påvirke knoglesundheden, målt som Bone Health Index (BHI), hos børn med mild til moderat CP. Metode: Tredive børn (14 piger; gennemsnitsalder 9,64 år) blev rekrutteret ved deres årlige kontrol på Herlev Universitetshospital. Deltagerne gennemgik en klinisk vurdering med journalgennemgang, ernæringsvurdering (herunder BMI), pubertetsvurdering (Tanner-skala), blodprøve til bestemmelse af D-vitamin og røntgen af venstre hånd/håndled. Knoglealder og BHI blev vurderet med BoneXpert, og motorisk funktion blev klassificeret med GMFCS. Der blev anvendt parret t-test og multipel regression (signifikans p < 0,05). Resultater: Der var ingen signifikant forskel mellem kronologisk alder og knoglealder for hvert køn, og der sås ingen kønsforskel i BHI. BHI afveg fra referenceværdierne i BoneXpert for nogle børn, hvilket peger på, at enkelte kan have lavere BHI end raske jævnaldrende, men samlet set var BHI ikke signifikant anderledes. Pubertetsstatus og GMFCS var associeret med knoglesundhed, og postpubertale børn havde lavere gennemsnitlig BHI end præpubertale. Konklusion: Børn med mild til moderat CP havde overordnet set normal knoglealder og ingen samlet signifikant ændring i BHI sammenlignet med raske børn, om end gennemsnittet lå lidt under reference. Yderligere forskning er nødvendig for at afklare betydningen af disse fund og om klinisk behandling bør tilpasses.
Background: Children with cerebral palsy (CP) commonly experience growth and bone health challenges. This pilot study examined the relationship between bone age and chronological age and explored factors that may influence bone health, expressed as the Bone Health Index (BHI), in children with mild to moderate CP. Methods: Thirty children (14 females; mean age 9.64 years) were recruited at their annual review at Herlev University Hospital. Participants underwent a clinical assessment including medical history, nutritional evaluation (including BMI), pubertal staging (Tanner scale), a vitamin D blood test, and an X-ray of the left hand/wrist. Bone age and BHI were assessed using BoneXpert, and gross motor function was classified by GMFCS. Statistical analyses included paired t-tests and multiple regression (significance p < 0.05). Results: No significant differences were found between chronological and bone age for each sex, and no sex differences in BHI were observed. BHI values deviated from BoneXpert normative data in some children, suggesting that some may have lower BHI than typically developing peers; however, overall BHI was not significantly different. Pubertal status and GMFCS were associated with bone health, with lower mean BHI in postpubertal compared with prepubertal children. Conclusion: Children with mild to moderate CP had bone ages comparable to their chronological ages and no overall significant difference in BHI versus healthy peers, although mean BHI tended to be slightly below average. Further research is needed to clarify these findings and inform potential adjustments to clinical care.
[This summary has been generated with the help of AI directly from the project (PDF)]
Keywords
Documents