Assembly of Magneto-Fluorescent Supernanoparticles for use as Drug Delivery Vehicles
Author
Bojesen, Aske Bredow
Term
4. term
Education
Publication year
2020
Submitted on
2020-06-03
Pages
70
Abstract
Dette arbejde beskriver, hvordan vi samlede magneto-fluorescerende supernanopartikler, dvs. større strukturer bygget af nanoskala byggesten, med henblik på fremtidig lægemiddellevering. Ideen er at kombinere magnetiske jernoxid-nanopartikler, som kan styres med en magnet, med lysudsendende kvanteprikker, så bærerne kan spores ved deres lys. Jernoxid-nanopartikler blev fremstillet ved to metoder: koprecipitation og termisk nedbrydning. CdSe-kvanteprikker blev syntetiseret med to varianter af termisk nedbrydning og derefter belagt med en CdS-skal for at øge fluorescensen. Til sidst blev de fremstillede jernoxid-nanopartikler og CdS-belagte kvanteprikker samlet til sammensatte supernanopartikler. Disse viste tydelig magneto-fluorescerende adfærd: de reagerede på magnetfelter og udsendte lys, hvilket viser, at begge funktioner er kombineret i samme struktur.
This thesis describes how we assembled magneto-fluorescent supernanoparticles—larger structures built from nanoscale building blocks—intended for future drug delivery. The idea is to combine magnetic iron oxide nanoparticles, which allow guidance with a magnet, with light-emitting quantum dots so the carriers can be tracked by their glow. Iron oxide nanoparticles were produced by two routes: co-precipitation and thermal decomposition. CdSe quantum dots were synthesized by two variations of thermal decomposition and then coated with a CdS shell to increase fluorescence. Finally, the iron oxide nanoparticles and the CdS-coated quantum dots were assembled into composite supernanoparticles. These showed clear magneto-fluorescent behavior: they responded to magnetic fields and emitted light, demonstrating that both functions were successfully combined in the same structure.
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