Clinical knowledge is ever growing and evidence based clinical guidelines have started to play an increasingly bigger role in today's standardized care. For many years, guidelines have helped to both improve the quality of patient-care and -safety. However, implementation of guidelines has shown limited success, and methods of implementation do highly vary between regions, which results in high variation in quality of treatment as well. In recent years, clinical checklists have been gaining more attention, as their use in clinical practice, to help ensure compliance with clinical guidelines, has shown promising results. Nevertheless, there is still lack of coherence between the checklists being used and the clinical-knowledge they are complying with. It is clear that if guidelines are to comply with the future state of healthcare their use in a clinical setting needs to be reconsidered, preferably with the use of an IT based solution. The project's objective was therefore set on defining, and evaluating, requirements which could enable prediction of such a clinical-information-system. A proof of concept, called CliniCheck, was developed and implemented into a functioning web-application, which exemplifies how guidelines and checklists can be implemented and used within a surgery pathway in a hospital setting. CliniCheck served to fulfill the requirements identified, while also taking into account the seven characteristics of healthcare described by Garde and Knaup [2006]. Although CliniCheck serves to only exemplify the requirements within a surgery pathway, the model still manages to illustrate how a checklist-based guideline systems could function in practice. Nevertheless, if the requirements are to be used for predicting a clinical guideline system, more extensive evaluation and design-input is needed from its end-users.