Polymeric micelles as drug delivery system and MRI contrast agent

Student thesis: Master thesis (including HD thesis)

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  • Sven Buskov Romme
4. term, Nanotechnology, Master (Master Programme)
The thesis explored the potential application of amphiphilic PVP micelles as drug delivery system and gadolinium MRI contrast agent. PVP micelles were produced in 30 to 100 nm size range, and their drug delivery ability was investigated. Glioblastoma and fibroblast cells were exposed to curcumin loaded PVP micelles in the presence of endocytic inhibitors, dynasore and wortmannin, and drug uptake was observed within 5 minutes of exposure across all experimental lines.

The curcumin loaded PVP micelles were functionalised by gadolinium to serve as a contrast agent for \textit{in vivo} MRI scan of nude mice. An intravascular T1 weighted signal was observed, of about half the magnitude compared to commercial agent Dotarem as reference.

The enhanced permeability and retention time (EPR) effect was observed in the tumour of the mouse subject to sample of strongest signal intensity, by the accumulated signal after 24 hours.
SpecialisationNanobiotechnology
LanguageEnglish
Publication date15 Sep 2015
Number of pages91

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ID: 218922445