The objective of this thesis is to investigate Separate Meter-In Separate Meter-Out, SMISMO, control strategies for a hydraulic cylinder. In the first part of the thesis, highly independent control combinations were found and analysed. An analytical Relative Gain Array analysis concluded that the cross coupling are heavy for certain frequencies and that the suggested input-output pairing change when varying the piston position. In the second part of the thesis, a given hydraulic system was modelled, validated, and analysed. A worst-case linearisation point was chosen and the system was found to be ill-conditioned. Three MIMO controllers were designed for velocity and pressure and compared: Pole Placement, Linear Quadratic Regulator, and Linear Quadratic Integral, LQI, controller. The LQI controller proved good results in regards to transient response, steady state accuracy, parameter variation, and disturbance rejection.