Background and aims: Chronic pancreatitis (CP) is a fibro-inflammatory disease with risk of developing exocrine pancreatic insufficiency (EPI) resulting in malnutrition. Substudy 1 (meta-analysis) aims to outline the pooled prevalence of micronutritional deficiencies and macronutritional abnormalities among CP outpatients. Substudy 2 (cross-sectional study) investigates prevalence of the micronutritional deficiencies and macronutritional abnormalities in a cross-sectional study of a Danish population of CP outpatients, and examines the association between nutritional status, EPI and/or PERT, and the association between micronutrients and macronutritional assessment parameters in CP outpatients. Methods: In substudy 1, original articles reporting prevalence estimates on deficiencies were collected. Pooled prevalences and heterogeneity of selected nutrients were calculated. For substudy 2, outpatients with CP from AAUH were enrolled between January 2012 through May 2017. Assessments were collected through routine clinical examination, blood samples, bioelectrical impedance, and specific functional tests. Prevalences of deficiencies were estimated, and the association between nutritional status, EPI and/or PERT, and association between micronutrients and macronutritional assessment parameters were calculated. Results: For substudy 1, pooled prevalences were: 21.0% for vitamin A deficiency, 31.0% for vitamin E deficiency, 50.0% for vitamin D deficiency, 68.0% for vitamin D insufficiency, 11.0% for BMI <18.5 kg/m2, and 19.0% for BMI <20.0 kg/m2 with noteworthy heterogeneity. In substudy 2, 137 patients with CP were enrolled. Most frequent deficiencies were: 29.2% for albumin deficiency, 26.3% for vitamin D insufficiency, 21.9% for vitamin D deficiency, 19.7% for zinc deficiency, 16.8% for magnesium deficiency, and 17.4% had sarcopenia. An association to EPI and/or PERT were found for vitamin A (p = 0.008), vitamin E (p = 0.000), vitamin B12 (p=0.027), magnesium (p = 0.038), and sarcopenia (p = 0.032). BMI was associated with zinc (p = 0.002). Sarcopenia was associated with vitamin E (p = 0.019), vitamin B12 (p = 0.049), and zinc (p = 0.003). Phase angel was associated with vitamin E (p = 0.014), magnesium (p = 0.041), and zinc (p = 0.088) Conclusion: For substudy 1, a large heterogeneity was shown between studies for most of the existing estimates on malnutrition in patients with CP. For substudy 2, the prevalence of malnutrition seem lower in Danish outpatients with CP compared to the estimates provided from the existing literature. There are no clear association between malnutrition and the presence of EPI and use of PERT for most nutritional parameters. Also the 2 of 28 association between micronutrients and macronutritional assessment parameter are generally poor, but a strong correlation between zinc and macronutritional assessment parameters was found, and requires more investigation.