This work entitled “The Role of Entrepreneurs in Developing Economies: Case of Cameroon”, takes into consideration a holistic view of entrepreneurship with the Entrepreneurship Ecosystem being at the epicenter of the discussion. The up to date literature and theory of the entrepreneurial ecosystem pining individual and institutional factors as key variables for a healthy Entrepreneurship Ecosystem was exploited. To determine the health of the Cameroon Entrepreneurship Ecosystem and ascertain the role and impact Cameroonian entrepreneurs have in the economy, a mix method methodology was deployed and after findings and analysis the Cameroon Entrepreneurship Ecosystem was seen as unhealthy. Amidst the findings and the unhealthy Business Environment which has taken a toll on entrepreneurs, their role and impact on the economy of Cameroon is undisputed. Findings also reveal that a healthy business climate is vital for the enhancement of the role and impact Cameroonian Entrepreneurs have in the economy. This role and impact, will go a long way to help catalyse Cameroon’s emergency and the quest for a double digit GDP growth by 2035. The study ends up by presenting the key challenges of the Cameroon business climate different stakeholders and to the entrepreneurs in particular while proposing policy recommendations that if adopted and efficiently implemented will be the game changer for entrepreneurs and Cameroon’s emergence.