Fremstilling af vand-uopløste cyclodekstrin baseret fibre gennem elektrospinning og foto-krydsbinding
Translated title
Formation of Water-Insoluble Cyclodextrin-based Fibres by Electrospinning and Photo-Crosslinking
Author
Thygesen, Sarah
Term
4. Term
Education
Publication year
2024
Pages
114
Abstract
Water pollution is a global challenge, and new materials are needed to capture unwanted compounds. This project develops water‑insoluble, ultrathin fibers made from two sugar‑based polymers: cyclodextrins (ring‑shaped sugars that can host small molecules) and dextran. Cyclodextrins are crosslinked with epichlorohydrin, ethylene glycol diglycidyl ether (EGDGE), poly(ethylene glycol) diglycidyl ether (PEGDGE), or dextran to form polymer networks. In addition, dextran is modified with benzophenone, a photoinitiated crosslinker, so it can be UV‑cured to form covalent bonds. Fibers are produced by electrospinning, a process that uses a high voltage to draw polymer solutions into very thin fibers. This is achieved for all systems except the PEGDGE‑crosslinked cyclodextrin. Electrospinning conditions (solvent, concentration, and voltage) are optimized. The fibers are UV‑cured, and dissolution tests confirm they are water‑insoluble. Their morphology before and after the dissolution test is examined by scanning electron microscopy (SEM). Finally, the fibers’ ability to take up aroma molecules based on trans‑anethole and 4‑allylanisole is tested in water. In the aqueous phase, the fibers absorb 75–135% of the theoretical amount that an equivalent amount of dissolved β‑cyclodextrin would be expected to take up. These results indicate that electrospun, UV‑cured, sugar‑based fibers can capture small organic molecules from water.
Forurening af vand er et globalt problem, og der er behov for materialer, der kan fange uønskede stoffer. I dette projekt fremstilles vanduopløselige, meget tynde fibre af to typer sukkerbaserede polymerer: cyclodextriner (ringformede sukkermolekyler, der kan indkapsle små molekyler) og dextran. Cyclodextrinerne tværbindes med enten epiklorhydrin, ethylenglycol-diglycidylether (EGDGE), poly(ethylenglycol)-diglycidylether (PEGDGE) eller dextran for at danne polymernetværk. Derudover modificeres dextran med benzofenon, en fototværbinder, så det kan UV-hærdes og danne kovalente bindinger. Fibre fremstilles ved elektrospinning, en metode hvor et elektrisk felt trækker en polymeropløsning ud til ultratynde fibre. Det lykkes for alle systemer undtagen cyclodextrin tværbundet med PEGDGE. Parametre for elektrospinning optimeres (valg af opløsningsmiddel, koncentration og spænding). De fremstillede fibre UV-hærdes, og en opløsningstest bekræfter, at de ikke opløses i vand. Fibrenes udseende før og efter opløsningstesten undersøges med scanning elektronmikroskopi (SEM). Til sidst vurderes fibrenes evne til at optage aromastoffer baseret på trans-anethol og 4-allylanisol i vand. I den vandige fase absorberer fibrene 75–135% af den teoretiske mængde, som en tilsvarende mængde opløst β-cyklodextrin forventes at optage. Resultaterne viser, at disse sukkerbaserede, elektrospundne og UV-hærdede fibre har potentiale til at indfange små organiske molekyler i vand.
[This apstract has been rewritten with the help of AI based on the project's original abstract]
Keywords